Ozempic’s Older Sibling Would possibly Sluggish Down Alzheimer’s

An older sibling of the favored diabetes and weight reduction drug semaglutide might assist gradual the development of Alzheimer’s illness. In medical trial knowledge launched this week, UK scientists have discovered proof that liraglutide can scale back mind shrinkage and cognitive decline in Alzheimer’s sufferers. Semaglutide is already being examined out in bigger Section III trials for the neurodegenerative situation.

Liraglutide and comparable medication mimic the hormone GLP-1, which helps regulate our blood sugar and urge for food. It was accredited in 2010 to deal with sort 2 diabetes; in 2014, it was accredited to deal with weight problems. Individuals with poorly managed diabetes are identified to be at larger danger for Alzheimer’s and different types of dementia, whereas some research in animals have suggested that liraglutide can stop the damaging mind adjustments that happen in Alzheimer’s. So scientists on the Imperial School London determined to conduct a double-blinded, randomized, and placebo-controlled trial of liraglutide for Alzheimer’s.

The trial concerned 204 sufferers identified with early Alzheimer’s, half of whom got liraglutide. The drug didn’t seem to considerably change folks’s glucose metabolism within the mind, which was the first measure of the research. However the researchers did discover that individuals on liraglutide skilled an nearly 50% slower decline in mind quantity loss than folks taking placebo over the following yr. These on the drug additionally skilled an 18% slower decline in measured cognitive operate throughout that point. The group’s findings had been introduced this week on the Alzheimer’s Affiliation Worldwide Convention.

This analysis is preliminary; it hasn’t but gone via the peer-review course of. And assuming the outcomes are legitimate, it’s nonetheless not clear precisely how liraglutide could be enhancing folks’s brains for the higher. However the researchers do have a number of potential explanations.

“We predict liraglutide is defending the mind probably by lowering irritation, decreasing insulin resistance and the poisonous results of Alzheimer’s biomarkers or enhancing how the mind’s nerve cells talk,” mentioned research researcher Paul Edison, a professor of neuroscience at Imperial’s Division of Mind Sciences, in a statement from the college.

Maybe essentially the most thrilling a part of this analysis is that stronger GLP-1 medication have emerged since this research started, corresponding to semaglutide. Semaglutide (bought underneath the names Ozempic and Wegovy) and the even newer tirzepatide (Mounjaro and Zepbound) have confirmed to be considerably more practical at treating diabetes and weight problems than older GLP-1 medicines like liraglutide. And a research printed simply final month has already found proof that semaglutide can enhance mind well being in folks with sort 2 diabetes.

The makers of each liraglutide and semaglutide, Novo Nordisk, are at the moment conducting two large-scale, placebo-controlled trials to see whether or not semaglutide can enhance the trajectory of individuals identified with early Alzheimer’s illness. If these outcomes, anticipated to reach inside the subsequent few years, are optimistic, they need to result in semaglutide and different GLP-1 medication changing into the most recent device in a rising arsenal of anti-Alzheimer’s medicines.